APPLICATIONS

 

How KiNativ™ Integrates Into Your Drug Discovery and Development Efforts

• Drug selectivity screening in biological samples such as cell or tissue lysates across species
• Inhibitor profiling directly at the site of efficacy or toxicity for determination of mechanism of action
• Simultaneous evaluation of potency (IC50) against targets and off-targets
• Exploration of structure function against targets and off-targets for lead optimization
• Biomarker identification

ActivX Offers a Wide Range of Approaches for Working with Pharmaceutical and Biotechnology Companies Solutions

• Inhibitor profiling against pre-characterized panels with a rapidly growing list of >200 human kinases
• IC 50determination against pre-characterized panels of >200 human kinases
  • Customized projects in clinically relevant samples from any species with the potential of profiling against over 400 kinases
• Collaborative partnerships addressing all stages of drug development for protein kinases and other important enzyme classes

Custom Solutions

In addition to our kinase platform, ActivX has developed technology to interrogate several other major drugable protein classes including:

• Other ATP/ADP and GTP/ GDP binding proteins
• Serine hydrolases
• Cysteine proteases
• Metalloproteinases
• Oxidoreductases

Application-specific Details

Several application-specific details are covered in our list of "Frequently Asked Questions (FAQ)"!